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- October 1906
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Mitsui Hachirouemon, representing the Mitsui family, establishes the Mitsui Charity Hospital as an incorporated foundation
- March 1909
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The Hospital is formally opened on the site of the former Tokyo Imperial University Second Hospital in Kanda-Izumicho, Chiyoda-ku, Tokyo
- April 1919
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The name is changed to Izumibashi Charity Hospital
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- July 1943
- The name is changed to Mitsui Public Welfare Hospital
- March 1945
- The buildings and attached facilities are destroyed by fire bombs
- August 1947
- Major repairs are completed on two 3-story reinforced concrete buildings
- April 1951
- Expansion of wards by 500 sq.m., with 50 new beds
- May 1952
- The name is changed to Mitsui Welfare Hospital, a social welfare corporation
- November 1956
- Expansion of wards by 780 sq. m., with 58 new beds
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- April 1970
- The name is changed to Mitsui Memorial Hospital, a social welfare corporation
The old buildings are dismantled, and the first stage of construction of the present buildings is completed (Ward Blocks B and C)
- April 1980
- The second stage of construction is completed (Ward Block D)
- April 1983
- The third stage of construction is completed (Nursing School, Nurses' Residence)
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- August 1993
- The Administration Building is completed
- August 1994
- The Comprehensive Examination Center is completed
- May 2002
- Mitsui Yokoen Special Nursing Home for the Elderly
- March 2004
- The Mitsui Memorial Hospital Nursing School is opened in Koto-ku
- December 2008
- Opening of the Inpatient Wards
- September 2010
- Opening of the Outpatient Ward Block
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